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PAR Genes : Molecular Probes to Pathological Assessment in Breast Cancer Progression
Joint Authors
Maoz, Myriam
Cohen, Irit
Turm, Hagit
Bar-Shavit, Rachel
Maly, Bella
Uziely, Beatrice
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Taking the issue of tumor categorization a step forward and establish molecular imprints to accompany histopathological assessment is a challenging task.
This is important since often patients with similar clinical and pathological tumors may respond differently to a given treatment.
Protease-activated receptor-1 (PAR1), a G protein-coupled receptor (GPCR), is the first member of the mammalian PAR family consisting of four genes.
PAR1 and PAR2 play a central role in breast cancer.
The release of N-terminal peptides during activation and the exposure of a cryptic internal ligand in PARs, endow these receptors with the opportunity to serve as a “mirror-image” index reflecting the level of cell surface PAR1&2-in body fluids.
It is possible to use the levels of PAR-released peptide in patients and accordingly determine the choice of treatment.
We have both identified PAR1 C-tail as a scaffold site for the immobilization of signaling partners, and the critical minimal binding site.
This binding region may be used for future therapeutic modalities in breast cancer, since abrogation of the binding inhibits PAR1 induced breast cancer.
Altogether, both PAR1 and PAR2 may serve as molecular probes for breast cancer diagnosis and valuable targets for therapy.
American Psychological Association (APA)
Uziely, Beatrice& Turm, Hagit& Maoz, Myriam& Cohen, Irit& Maly, Bella& Bar-Shavit, Rachel. 2011. PAR Genes : Molecular Probes to Pathological Assessment in Breast Cancer Progression. Pathology Research International،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-452126
Modern Language Association (MLA)
Uziely, Beatrice…[et al.]. PAR Genes : Molecular Probes to Pathological Assessment in Breast Cancer Progression. Pathology Research International No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-452126
American Medical Association (AMA)
Uziely, Beatrice& Turm, Hagit& Maoz, Myriam& Cohen, Irit& Maly, Bella& Bar-Shavit, Rachel. PAR Genes : Molecular Probes to Pathological Assessment in Breast Cancer Progression. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-452126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452126