The Expression of Selected Proapoptotic Molecules in Dermatitis Herpetiformis
Joint Authors
Waszczykowska, Elzbieta
Marian, Danilewicz
Cynkier, Anna
Zebrowska, Agnieszka
Anna, Erkiert-Polguj
Wagrowska-Danilewicz, Malgorzata
Anna, Sysa-Jedrzejowska
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The role of the process of apoptosis is investigated in the pathogenesis of many autoimmune diseases; however at present, there is not much information about its role in dermatitis herpetiformis.
Skin biopsies were taken from 18 DH patients and from 10 healthy subjects.
The localization and expression of Bax, Fas, FasL, TRAIL, TRAIL-R in skin lesions, and perilesional skin were studied by immunohistochemistry.
Expression of Bax, Fas, and Fas ligand was detected in the keratinocytes in skin biopsies from DH patients.
Expression of TRAIL and TRAIL receptor was confirmed in epidermis, infiltration cells, and some fibroblasts.
The expression of examined molecules in biopsies from healthy people was observed only in single cells.
There were statistically significant differences between lesional, perilesional, and healthy skin of control group in Bax expression analysis and between lesional skin and control group in Fas, FasL, and TRAIL expression.
There were statistically significant differences between control group and perilesional skin in Bax and FasL expression.
Our results show that selected proapoptotic molecules may take part in pathogenesis of dermatitis herpetiformis, but the role of apoptosis in this process is not clear.
American Psychological Association (APA)
Zebrowska, Agnieszka& Anna, Erkiert-Polguj& Wagrowska-Danilewicz, Malgorzata& Marian, Danilewicz& Anna, Sysa-Jedrzejowska& Cynkier, Anna…[et al.]. 2012. The Expression of Selected Proapoptotic Molecules in Dermatitis Herpetiformis. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-452134
Modern Language Association (MLA)
Zebrowska, Agnieszka…[et al.]. The Expression of Selected Proapoptotic Molecules in Dermatitis Herpetiformis. Clinical and Developmental Immunology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-452134
American Medical Association (AMA)
Zebrowska, Agnieszka& Anna, Erkiert-Polguj& Wagrowska-Danilewicz, Malgorzata& Marian, Danilewicz& Anna, Sysa-Jedrzejowska& Cynkier, Anna…[et al.]. The Expression of Selected Proapoptotic Molecules in Dermatitis Herpetiformis. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-452134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452134