Amino Acid Derivatives as New Zinc Binding Groups for the Design of Selective Matrix Metalloproteinase Inhibitors
Joint Authors
Bertamino, Alessia
Vernieri, Ermelinda
Agamennone, Mariangela
Nuti, Elisa
Rossello, Armando
Tortorella, Paolo
Di Pizio, Antonella
Gomez-Monterrey, Isabel
Novellino, Ettore
Sala, Marina
Campiglia, Pietro
Carotenuto, Alfonso
Giustiniano, Mariateresa
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
A number of matrix metalloproteinases (MMPs) are important medicinal targets for conditions ranging from rheumatoid arthritis to cardiomyopathy, periodontal disease, liver cirrhosis, multiple sclerosis, and cancer invasion and metastasis, where they showed to have a dual role, inhibiting or promoting important processes involved in the pathology.
MMPs contain a zinc (II) ion in the protein active site.
Small-molecule inhibitors of these metalloproteins are designed to bind directly to the active site metal ions.
In an effort to devise new approaches to selective inhibitors, in this paper, we describe the synthesis and preliminary biological evaluation of amino acid derivatives as new zinc binding groups (ZBGs).
The incorporation of selected metal-binding functions in more complex biphenyl sulfonamide moieties allowed the identification of one compound able to interact selectively with different MMP enzymatic isoforms.
American Psychological Association (APA)
Giustiniano, Mariateresa& Tortorella, Paolo& Agamennone, Mariangela& Di Pizio, Antonella& Rossello, Armando& Nuti, Elisa…[et al.]. 2013. Amino Acid Derivatives as New Zinc Binding Groups for the Design of Selective Matrix Metalloproteinase Inhibitors. Journal of Amino Acids،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-452140
Modern Language Association (MLA)
Giustiniano, Mariateresa…[et al.]. Amino Acid Derivatives as New Zinc Binding Groups for the Design of Selective Matrix Metalloproteinase Inhibitors. Journal of Amino Acids No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-452140
American Medical Association (AMA)
Giustiniano, Mariateresa& Tortorella, Paolo& Agamennone, Mariangela& Di Pizio, Antonella& Rossello, Armando& Nuti, Elisa…[et al.]. Amino Acid Derivatives as New Zinc Binding Groups for the Design of Selective Matrix Metalloproteinase Inhibitors. Journal of Amino Acids. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-452140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452140