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Anti-Inflammatory Effect of Emblica officinalis in Rodent Models of Acute and Chronic Inflammation : Involvement of Possible Mechanisms
Joint Authors
Ojha, Shreesh
Bhatia, Jagriti
Sarangal, Vikas
Golechha, Mahaveer
Arya, Dharmveer S.
Source
International Journal of Inflammation
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Emblica officinalis, commonly known as amla in Ayurveda, is unarguably the most important medicinal plant for prevention and treatment of various ailments.
The present study investigated the anti-inflammatory activity of hydroalcoholic extract of Emblica officinalis (HAEEO).
Acute inflammation in rats was induced by the subplantar injection of carrageenan, histamine, serotonin, and prostaglandin E2 and chronic inflammation was induced by the cotton pellet granuloma.
Intraperitoneal (i.p.) administration of HAEEO at all the tested doses (300, 500, and 700 mg/kg) significantly (P<0.001) inhibited rat paw edema against all phlogistic agents and also reduced granuloma formation.
However, at the dose of 700 mg/kg, HAEEO exhibited maximum anti-inflammatory activity in all experimental models, and the effects were comparable to that of the standard anti-inflammatory drugs.
Additionally, in paw tissue the antioxidant activity of HAEEO was also measured and it was found that HAEEO significantly (P<0.001) increased glutathione, superoxide dismutase, and catalase activity and subsequently reduced lipid peroxidation evidenced by reduced malondialdehyde.
Taken all together, the results indicated that HAEEO possessed potent anti-inflammatory activity and it may hold therapeutic promise in the management of acute and chronic inflammatory conditions.
American Psychological Association (APA)
Golechha, Mahaveer& Sarangal, Vikas& Ojha, Shreesh& Bhatia, Jagriti& Arya, Dharmveer S.. 2014. Anti-Inflammatory Effect of Emblica officinalis in Rodent Models of Acute and Chronic Inflammation : Involvement of Possible Mechanisms. International Journal of Inflammation،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-452142
Modern Language Association (MLA)
Golechha, Mahaveer…[et al.]. Anti-Inflammatory Effect of Emblica officinalis in Rodent Models of Acute and Chronic Inflammation : Involvement of Possible Mechanisms. International Journal of Inflammation No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-452142
American Medical Association (AMA)
Golechha, Mahaveer& Sarangal, Vikas& Ojha, Shreesh& Bhatia, Jagriti& Arya, Dharmveer S.. Anti-Inflammatory Effect of Emblica officinalis in Rodent Models of Acute and Chronic Inflammation : Involvement of Possible Mechanisms. International Journal of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-452142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452142