Versatility of RNA-Binding Proteins in Cancer
Author
Source
Comparative and Functional Genomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Posttranscriptional gene regulation is a rapid and efficient process to adjust the proteome of a cell to a changing environment.
RNA-binding proteins (RBPs) are the master regulators of mRNA processing and translation and are often aberrantly expressed in cancer.
In addition to well-studied transcription factors, RBPs are emerging as fundamental players in tumor development.
RBPs and their mRNA targets form a complex network that plays a crucial role in tumorigenesis.
This paper describes mechanisms by which RBPs influence the expression of well-known oncogenes, focusing on precise examples that illustrate the versatility of RBPs in posttranscriptional control of cancer development.
RBPs appeared very early in evolution, and new RNA-binding domains and combinations of them were generated in more complex organisms.
The identification of RBPs, their mRNA targets, and their mechanism of action have provided novel potential targets for cancer therapy.
American Psychological Association (APA)
Wurth, Laurence. 2012. Versatility of RNA-Binding Proteins in Cancer. Comparative and Functional Genomics،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-452153
Modern Language Association (MLA)
Wurth, Laurence. Versatility of RNA-Binding Proteins in Cancer. Comparative and Functional Genomics No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-452153
American Medical Association (AMA)
Wurth, Laurence. Versatility of RNA-Binding Proteins in Cancer. Comparative and Functional Genomics. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-452153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452153