S100A1 : A Regulator of Striated Muscle Sarcoplasmic Reticulum Ca2+ Handling, Sarcomeric, and Mitochondrial Function
Joint Authors
Goodman, Chelain
Völkers, Mirko
Rohde, David
Most, Patrick
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Calcium (Ca2+) signaling plays a key role in a wide range of physiological functions including control of cardiac and skeletal muscle performance.
To assure a precise coordination of both temporally and spatially transduction of intracellular Ca2+ oscillations to downstream signaling networks and target operations, Ca2+ cycling regulation in muscle tissue is conducted by a plethora of diverse molecules.
Ca2+ S100A1 is a member of the Ca2+-binding S100 protein family and represents the most abundant S100 isoform in cardiac and skeletal muscle.
Early studies revealed distinct expression patterns of S100A1 in healthy and diseased cardiac tissue from animal models and humans.
Further elaborate investigations uncovered S100A1 protein as a basic requirement for striated muscle Ca2+ handling integrity.
S100A1 is a critical regulator of cardiomyocyte Ca2+ cycling and contractile performance.
S100A1-mediated inotropy unfolds independent and on top of βAR-stimulated contractility with unchanged βAR downstream signaling.
S100A1 has further been detected at different sites within the cardiac sarcomere indicating potential roles in myofilament function.
More recently, a study reported a mitochondrial location of S100A1 in cardiomyocytes.
Additionally, normalizing the level of S100A1 protein by means of viral cardiac gene transfer in animal heart failure models resulted in a disrupted progression towards cardiac failure and enhanced survival.
This brief review is confined to the physiological and pathophysiological relevance of S100A1 in cardiac and skeletal muscle Ca2+ handling with a particular focus on its potential as a molecular target for future therapeutic interventions.
American Psychological Association (APA)
Völkers, Mirko& Rohde, David& Goodman, Chelain& Most, Patrick. 2010. S100A1 : A Regulator of Striated Muscle Sarcoplasmic Reticulum Ca2+ Handling, Sarcomeric, and Mitochondrial Function. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-452161
Modern Language Association (MLA)
Völkers, Mirko…[et al.]. S100A1 : A Regulator of Striated Muscle Sarcoplasmic Reticulum Ca2+ Handling, Sarcomeric, and Mitochondrial Function. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-452161
American Medical Association (AMA)
Völkers, Mirko& Rohde, David& Goodman, Chelain& Most, Patrick. S100A1 : A Regulator of Striated Muscle Sarcoplasmic Reticulum Ca2+ Handling, Sarcomeric, and Mitochondrial Function. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-452161
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452161