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Sphingolipid Metabolic Pathway : An Overview of Major Roles Played in Human Diseases
Joint Authors
Pralhada Rao, Raghavendra
Mammen Oommen, Anup
Somaiya, Neeti
Jagannath, M. R.
Rengasamy, Mathiyazhagan
Vaidyanathan, Nanditha
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Sphingolipids, a family of membrane lipids, are bioactive molecules that participate in diverse functions controlling fundamental cellular processes such as cell division, differentiation, and cell death.
Given that most of these cellular processes form the basis for several pathologies, it is not surprising that sphingolipids are key players in several pathological processes.
This review discusses the role of the sphingolipid metabolic pathway in diabetes, Alzheimer’s disease, and hepatocellular carcinoma, with a special emphasis on the changes in gene expression pattern in these disease conditions.
For convenience, the sphingolipid metabolic pathway is divided into hypothetical compartments (modules) with each compartment representing a physiological process and changes in gene expression pattern are mapped to each of these modules.
It appears that alterations in the gene expression pattern in these disease conditions are biased to manipulate the system in order to result in a particular disease.
American Psychological Association (APA)
Pralhada Rao, Raghavendra& Vaidyanathan, Nanditha& Rengasamy, Mathiyazhagan& Mammen Oommen, Anup& Somaiya, Neeti& Jagannath, M. R.. 2013. Sphingolipid Metabolic Pathway : An Overview of Major Roles Played in Human Diseases. Journal of Lipids،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-452179
Modern Language Association (MLA)
Pralhada Rao, Raghavendra…[et al.]. Sphingolipid Metabolic Pathway : An Overview of Major Roles Played in Human Diseases. Journal of Lipids No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-452179
American Medical Association (AMA)
Pralhada Rao, Raghavendra& Vaidyanathan, Nanditha& Rengasamy, Mathiyazhagan& Mammen Oommen, Anup& Somaiya, Neeti& Jagannath, M. R.. Sphingolipid Metabolic Pathway : An Overview of Major Roles Played in Human Diseases. Journal of Lipids. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-452179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452179