A Paratransgenic Strategy for the Control of Chagas Disease
Joint Authors
Jose, Christo
Hurwitz, Ivy
Fieck, Annabeth
Klein, Nichole
Durvasula, Ravi
Kang, Angray
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Chagas disease results from infection with the parasite Trypanosoma cruzi.
This disease remains a significant cause of morbidity and mortality in central and south America.
Chagas disease now exists and is detected worldwide because of human migration.
Control of Chagas disease has relied mainly on vector eradication however, the development of insect resistance to pesticides, coupled with cost and adverse health effects of insecticide treatments, has prompted our group to investigate novel methods of transmission control.
Our laboratory has been instrumental in the development of the paratransgenic strategy to control vectorial transmission of T.
cruzi.
In this paper, we discuss various components of the paratransgenic approach.
Specifically, we describe classes of molecules that can serve as effectors, including antimicrobial peptides, endoglucanases, and highly specific single chain antibodies that target surface glycoprotein tags on the surface of T.
cruzi.
Furthermore, we address evolving concepts related to field dispersal of engineered bacteria as part of the paratransgenic control strategy and attendant risk assessment evaluation.
American Psychological Association (APA)
Hurwitz, Ivy& Fieck, Annabeth& Klein, Nichole& Jose, Christo& Kang, Angray& Durvasula, Ravi. 2012. A Paratransgenic Strategy for the Control of Chagas Disease. Psyche،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-452185
Modern Language Association (MLA)
Hurwitz, Ivy…[et al.]. A Paratransgenic Strategy for the Control of Chagas Disease. Psyche No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-452185
American Medical Association (AMA)
Hurwitz, Ivy& Fieck, Annabeth& Klein, Nichole& Jose, Christo& Kang, Angray& Durvasula, Ravi. A Paratransgenic Strategy for the Control of Chagas Disease. Psyche. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-452185
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452185