![](/images/graphics-bg.png)
β-Adrenergic Receptor-Stimulated Cardiac Myocyte Apoptosis : Role of β1 Integrins
Joint Authors
Amin, Parthiv
Singh, Mahipal
Singh, Krishna
Source
Journal of Signal Transduction
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Increased sympathetic nerve activity to the myocardium is a central feature in patients with heart failure.
Accumulation of catecholamines plays an important role in the pathogenesis of heart disease.
Acting via β-adrenergic receptors (β-AR), catecholamines (norepinephrine and isoproterenol) increase cardiac myocyte apoptosis in vitro and in vivo.
Specifically, β1-AR and β2-AR coupled to Gαs exert a proapoptotic action, while β2-AR coupled to Gi exerts an antiapoptotic action.
β1 integrin signaling protects cardiac myocytes against β-AR-stimulated apoptosis in vitro and in vivo.
Interaction of matrix metalloproteinase-2 (MMP-2) with β1 integrins interferes with the survival signals initiated by β1 integrins.
This paper will discuss background information on β-AR and integrin signaling and summarize the role of β1 integrins in β-AR-stimulated cardiac myocyte apoptosis.
American Psychological Association (APA)
Amin, Parthiv& Singh, Mahipal& Singh, Krishna. 2011. β-Adrenergic Receptor-Stimulated Cardiac Myocyte Apoptosis : Role of β1 Integrins. Journal of Signal Transduction،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-452195
Modern Language Association (MLA)
Amin, Parthiv…[et al.]. β-Adrenergic Receptor-Stimulated Cardiac Myocyte Apoptosis : Role of β1 Integrins. Journal of Signal Transduction No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-452195
American Medical Association (AMA)
Amin, Parthiv& Singh, Mahipal& Singh, Krishna. β-Adrenergic Receptor-Stimulated Cardiac Myocyte Apoptosis : Role of β1 Integrins. Journal of Signal Transduction. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-452195
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452195