Genetics of Common Polygenic Ischaemic Stroke : Current Understanding and Future Challenges
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Stroke is the third commonest cause of death and the major cause of adult neurological disability worldwide.
While much is known about conventional risk factors such as hypertension, diabetes and incidence of smoking, these environmental factors only account for a proportion of stroke risk.
Up to 50% of stroke risk can be attributed to genetic risk factors, although to date no single risk allele has been convincingly identified as contributing to this risk.
Advances in the field of genetics, most notably genome wide association studies (GWAS), have revealed genetic risks in other cardiovascular disease and these techniques are now being applied to ischaemic stroke.
This paper covers previous genetic studies in stroke including candidate gene studies, discusses the genome wide association approach, and future techniques such as next generation sequencing and the post-GWAS era.
The review also considers the overlap from other cardiovascular diseases and whether findings from these may also be informative in ischaemic stroke.
American Psychological Association (APA)
Bevan, Steve& Markus, Hugh S.. 2011. Genetics of Common Polygenic Ischaemic Stroke : Current Understanding and Future Challenges. Stroke Research and Treatment،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-452196
Modern Language Association (MLA)
Bevan, Steve& Markus, Hugh S.. Genetics of Common Polygenic Ischaemic Stroke : Current Understanding and Future Challenges. Stroke Research and Treatment No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-452196
American Medical Association (AMA)
Bevan, Steve& Markus, Hugh S.. Genetics of Common Polygenic Ischaemic Stroke : Current Understanding and Future Challenges. Stroke Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-452196
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452196