Sterol Lipid Metabolism in Down Syndrome Revisited : Down Syndrome Is Associated with a Selective Reduction in Serum Brassicasterol Levels
Joint Authors
Tansley, Gavin
Head, Elizabeth
Lütjohann, Dieter
Wellington, Cheryl L.
Holmes, Daniel T.
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Over the past 15 years, insights into sterol metabolism have improved our understanding of the relationship between lipids and common conditions such as atherosclerosis and Alzheimer’s Disease (AD).
A better understanding of sterol lipid metabolism in individuals with Down Syndrome (DS) may help elucidate how this population’s unique metabolic characteristics influence their risks for atherosclerosis and AD.
To revisit the question of whether sterol lipid parameters may be altered in DS subjects, we performed a pilot study to assess traditional serum sterol lipids and lipoproteins, as well as markers of sterol biosynthesis, metabolites, and plant sterols in 20 subjects with DS compared to age-matched controls.
Here we report that the levels of nearly all lipids and lipoproteins examined are similar to control subjects, suggesting that trisomy 21 does not lead to pronounced general alterations in sterol lipid metabolism.
However, the levels of serum brassicasterol were markedly reduced in DS subjects.
American Psychological Association (APA)
Tansley, Gavin& Holmes, Daniel T.& Lütjohann, Dieter& Head, Elizabeth& Wellington, Cheryl L.. 2012. Sterol Lipid Metabolism in Down Syndrome Revisited : Down Syndrome Is Associated with a Selective Reduction in Serum Brassicasterol Levels. Current Gerontology and Geriatrics Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-452217
Modern Language Association (MLA)
Tansley, Gavin…[et al.]. Sterol Lipid Metabolism in Down Syndrome Revisited : Down Syndrome Is Associated with a Selective Reduction in Serum Brassicasterol Levels. Current Gerontology and Geriatrics Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-452217
American Medical Association (AMA)
Tansley, Gavin& Holmes, Daniel T.& Lütjohann, Dieter& Head, Elizabeth& Wellington, Cheryl L.. Sterol Lipid Metabolism in Down Syndrome Revisited : Down Syndrome Is Associated with a Selective Reduction in Serum Brassicasterol Levels. Current Gerontology and Geriatrics Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-452217
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452217