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Levels of Circulating TIMP-2 and MMP2-TIMP2 Complex Are Decreased in Squamous Cervical Carcinoma
Joint Authors
Anne, Talvensaari-Mattila
Taina, Turpeenniemi-Hujanen
Source
Obstetrics and Gynecology International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-29
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Background.
The role of matrix metalloproteinase-2 and -9 (MMP-2, MMP-9) in matrix degradation and metastasis has been described in various tumors.
Their action is inhibited by their natural tissue inhibitor molecules TIMP-1 and -2.
Methods.
The study population consisted of 12 squamous cervical carcinoma patients and 27 healthy volunteer control patients.
MMP-9, MMP-2-TIMP-2 complex, TIMP-1, and TIMP-2 were analyzed from serum samples using enzyme-linked immunoassay (ELISA).
Results.
The mean levels of serum TIMP-2 and of MMP-2-TIMP-2 complex were higher in healthy controls compared to patients with a malignant tumor.
Serum TIMP-2 values decreased significantly from healthy controls (median 323 μg/l, range 305–342 μg/l) to malignant (median 136 μg/l, range 120–151 μg/l) squamous cervical carcinoma patients (P<.000).
Also, serum proMMP2-TIMP2 complex values decreased from control patients to squamous cervical carcinoma patients (P<.006).
Conclusion.
This paper shows that the levels of circulating TIMP-2 and that of MMP-2-TIMP-2 complex are lower in squamous cervical carcinoma patients than in healthy women.
American Psychological Association (APA)
Anne, Talvensaari-Mattila& Taina, Turpeenniemi-Hujanen. 2010. Levels of Circulating TIMP-2 and MMP2-TIMP2 Complex Are Decreased in Squamous Cervical Carcinoma. Obstetrics and Gynecology International،Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-452221
Modern Language Association (MLA)
Anne, Talvensaari-Mattila& Taina, Turpeenniemi-Hujanen. Levels of Circulating TIMP-2 and MMP2-TIMP2 Complex Are Decreased in Squamous Cervical Carcinoma. Obstetrics and Gynecology International No. 2010 (2010), pp.1-3.
https://search.emarefa.net/detail/BIM-452221
American Medical Association (AMA)
Anne, Talvensaari-Mattila& Taina, Turpeenniemi-Hujanen. Levels of Circulating TIMP-2 and MMP2-TIMP2 Complex Are Decreased in Squamous Cervical Carcinoma. Obstetrics and Gynecology International. 2010. Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-452221
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452221