2D MR Spectroscopy Combined with Prior-Knowledge Fitting Is Sensitive to HCV-Associated Cerebral Metabolic Abnormalities
Joint Authors
Castellon, Steven A.
Thames, April D.
Hinkin, Charles H.
Nagarajan, Rajakumar
Sarma, Manoj K.
Thomas, M. Albert
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
There is an evidence of neurocognitive dysfunction even in the absence of advanced liver disease in chronic hepatitis C virus (HCV) infection.
Brain metabolism has been investigated non-invasively using one-dimensional (1D) in vivo Magnetic Resonance Spectroscopy (MRS) over three decades.
Even though highly concentrated cerebral metabolites (N-acetylaspartate, creatine, choline, glutamate/glutamine, myo-inositol) have been detected using MRS, other metabolites at low concentrations (~1–3 mM or less) including glutathione, aspartate and GABA are quite difficult to observe using 1D MRS.
In order to resolve overlapping resonances from a number of metabolites, a remedy is to add a second spectral dimension to the existing 1D MRS.
Localized two-dimensional correlated spectroscopy (L-COSY) has been developed over the last decade to enhance the spectral dispersion by using the second spectral dimension.
We have evaluated this L-COSY technique in the frontal white/gray matter regions of 14 HCV+ (mean age of 56.2 years) and 14 HCV− (mean age of 46.6 years) subjects.
Our preliminary results showed significantly increased myo-inositol and glutathione in the HCV+ compared to the HCV− subjects.
Hence, glutathione and myo-inositol should be considered along with other metabolites as important markers of inflammation.
American Psychological Association (APA)
Nagarajan, Rajakumar& Sarma, Manoj K.& Thames, April D.& Castellon, Steven A.& Hinkin, Charles H.& Thomas, M. Albert. 2012. 2D MR Spectroscopy Combined with Prior-Knowledge Fitting Is Sensitive to HCV-Associated Cerebral Metabolic Abnormalities. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-452223
Modern Language Association (MLA)
Nagarajan, Rajakumar…[et al.]. 2D MR Spectroscopy Combined with Prior-Knowledge Fitting Is Sensitive to HCV-Associated Cerebral Metabolic Abnormalities. International Journal of Hepatology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-452223
American Medical Association (AMA)
Nagarajan, Rajakumar& Sarma, Manoj K.& Thames, April D.& Castellon, Steven A.& Hinkin, Charles H.& Thomas, M. Albert. 2D MR Spectroscopy Combined with Prior-Knowledge Fitting Is Sensitive to HCV-Associated Cerebral Metabolic Abnormalities. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-452223
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452223