Exosome in Tumour Microenvironment : Overview of the Crosstalk between Normal and Cancer Cells
Joint Authors
Fernandes, Alexandra R.
Baptista, Pedro Viana
Roma-Rodrigues, Catarina
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cancer development is a multistep process in which exosomes play important roles.
Exosomes are small vesicles formed in vesicular bodies in the endosomal network.
The major role of exosomes seems to be the transport of bioactive molecules between cells.
Depending on the cell of origin, exosomes are implicated in the regulation of several cellular events, with phenotypic consequences in recipient cells.
Cancer derived exosomes (CCEs) are important players in the formation of the tumour microenvironment by (i) enabling the escape of tumour cells to immunological system and help initiating the inflammatory response; (ii) acting in the differentiation of fibroblasts and mesenchymal cells into myofibroblasts; (iii) triggering the angiogenic process; and (iv) enhancing the metastatic evolution of the tumour by promoting epithelial to mesenchymal transformation of tumour cells and by preparing the tumour niche in the new anatomical location.
Since the finding that exosomes content resembles that of the cell of origin, they may be regarded as suitable biomarkers for cancer diagnosis, allowing for diagnosis and prognosis via a minimal invasive procedure.
Exosome involvement in cancer may open new avenues regarding therapeutics, such as vectors for targeted drug delivery.
American Psychological Association (APA)
Roma-Rodrigues, Catarina& Fernandes, Alexandra R.& Baptista, Pedro Viana. 2014. Exosome in Tumour Microenvironment : Overview of the Crosstalk between Normal and Cancer Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-452239
Modern Language Association (MLA)
Roma-Rodrigues, Catarina…[et al.]. Exosome in Tumour Microenvironment : Overview of the Crosstalk between Normal and Cancer Cells. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-452239
American Medical Association (AMA)
Roma-Rodrigues, Catarina& Fernandes, Alexandra R.& Baptista, Pedro Viana. Exosome in Tumour Microenvironment : Overview of the Crosstalk between Normal and Cancer Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-452239
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452239