Theories on the Pathogenesis of Endometriosis
Joint Authors
Sourial, Samer
Hapangama, Dharani K.
Tempest, Nicola
Source
International Journal of Reproductive Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Endometriosis is a common, chronic inflammatory disease defined by the presence of extrauterine endometrial tissue.
The aetiology of endometriosis is complex and multifactorial, where several not fully confirmed theories describe its pathogenesis.
This review examines existing theories on the initiation and propagation of different types of endometriotic lesions, as well as critically appraises the myriad of biologically relevant evidence that support or oppose each of the proposed theories.
The current literature suggests that stem cells, dysfunctional immune response, genetic predisposition, and aberrant peritoneal environment may all be involved in the establishment and propagation of endometriotic lesions.
An orchestrated scientific and clinical effort is needed to consider all factors involved in the pathogenesis of this multifaceted disease and to propose novel therapeutic targets to reach effective treatments for this distressing condition.
American Psychological Association (APA)
Sourial, Samer& Tempest, Nicola& Hapangama, Dharani K.. 2014. Theories on the Pathogenesis of Endometriosis. International Journal of Reproductive Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-452242
Modern Language Association (MLA)
Sourial, Samer…[et al.]. Theories on the Pathogenesis of Endometriosis. International Journal of Reproductive Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-452242
American Medical Association (AMA)
Sourial, Samer& Tempest, Nicola& Hapangama, Dharani K.. Theories on the Pathogenesis of Endometriosis. International Journal of Reproductive Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-452242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452242