Evaluation of the Influence of Formulation and Process Variables on Mechanical Properties of Oral Mucoadhesive Films Using Multivariate Data Analysis
Joint Authors
Jekl, Vladimír
Gajdziok, Jan
Vetchý, David
Hauptman, Karel
Dvořáčková, Kateřina
Muselík, Jan
Landová, Hana
Doležel, Petr
Knotek, Zdeněk
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oral mucosa is an attractive region for the local and systemic application of many drugs.
Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties.
This work was focused on preparation of nonmedicated carmellose-based films using both solvent casting and impregnation methods, respectively.
Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used.
In this experiment, puncture strength strongly correlated with tensile strength and could be used to obtain necessary information about the mechanical film characteristics in films prepared using both methods.
Puncture work and tensile work were not correlated in films prepared using the solvent casting method, as increasing the amount of glycerol led to an increase in the puncture work in thinner films.
All measured texture parameters in films prepared by impregnation were significantly smaller compared to films prepared by solvent casting.
Moreover, a relationship between the amount of glycerol and film thickness was observed, and a greater recalculated tensile/puncture strength was needed for an increased thickness in films prepared by impregnation.
American Psychological Association (APA)
Landová, Hana& Vetchý, David& Gajdziok, Jan& Doležel, Petr& Muselík, Jan& Dvořáčková, Kateřina…[et al.]. 2014. Evaluation of the Influence of Formulation and Process Variables on Mechanical Properties of Oral Mucoadhesive Films Using Multivariate Data Analysis. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-452245
Modern Language Association (MLA)
Landová, Hana…[et al.]. Evaluation of the Influence of Formulation and Process Variables on Mechanical Properties of Oral Mucoadhesive Films Using Multivariate Data Analysis. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-452245
American Medical Association (AMA)
Landová, Hana& Vetchý, David& Gajdziok, Jan& Doležel, Petr& Muselík, Jan& Dvořáčková, Kateřina…[et al.]. Evaluation of the Influence of Formulation and Process Variables on Mechanical Properties of Oral Mucoadhesive Films Using Multivariate Data Analysis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-452245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452245