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Absence of Autophagy-Related Proteins Expression Is Associated with Poor Prognosis in Patients with Colorectal Adenocarcinoma
Joint Authors
Cho, Young-Seok
Choi, Ji Hye
Lee, Myung Ah
Hong, Soon Uk
Park, Jin Hee
Ko, Yoon Ho
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background/Aim.
Autophagy, a cellular degradation process, has paradoxical roles in tumorigenesis and the progression of human cancers.
The aim of this study was to investigate the expression levels of autophagy-related proteins in colorectal cancer (CRC) and to evaluate their prognostic significance.
Methods.
This study is a retrospective review of immunohistochemical and clinicopathological data.
All specimens evaluated were obtained from 263 patients with colorectal cancer who had undergone surgery between November 1996 and August 2007.
The primary outcomes measured were the expression levels of three autophagy-related proteins (ATG5, BECN1/Beclin 1, and Microtubule-associated protein 1 light chain 3B (LC3B)) by immunohistochemistry and its association in clinicopathological parameters and patient survival.
Results.
The autophagy-related protein expression frequencies were 65.1% (151/232) for ATG5, 71.3% (174/244) for BECN1, and 74.7% (186/249) for LC3B for the 263 patients.
Correlation between the expression of autophagy-related proteins was significant for all protein pairs.
Multivariate analysis showed that negative LC3B expression and absence of autophagy-related proteins expression were independently associated with poor prognosis.
Conclusion.
Absence of autophagy-related proteins expression is associated with poor clinical outcome in CRC, suggesting that these proteins have potential uses as novel prognostic markers.
American Psychological Association (APA)
Choi, Ji Hye& Cho, Young-Seok& Ko, Yoon Ho& Hong, Soon Uk& Park, Jin Hee& Lee, Myung Ah. 2014. Absence of Autophagy-Related Proteins Expression Is Associated with Poor Prognosis in Patients with Colorectal Adenocarcinoma. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-452248
Modern Language Association (MLA)
Choi, Ji Hye…[et al.]. Absence of Autophagy-Related Proteins Expression Is Associated with Poor Prognosis in Patients with Colorectal Adenocarcinoma. Gastroenterology Research and Practice No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-452248
American Medical Association (AMA)
Choi, Ji Hye& Cho, Young-Seok& Ko, Yoon Ho& Hong, Soon Uk& Park, Jin Hee& Lee, Myung Ah. Absence of Autophagy-Related Proteins Expression Is Associated with Poor Prognosis in Patients with Colorectal Adenocarcinoma. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-452248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452248