Molecular Mechanisms of the Whole DNA Repair System : A Comparison of Bacterial and Eukaryotic Systems

Abstract EN

DNA is subjected to many endogenous and exogenous damages.

All organisms have developed a complex network of DNA repair mechanisms.

A variety of different DNA repair pathways have been reported: direct reversal, base excision repair, nucleotide excision repair, mismatch repair, and recombination repair pathways.

Recent studies of the fundamental mechanisms for DNA repair processes have revealed a complexity beyond that initially expected, with inter- and intrapathway complementation as well as functional interactions between proteins involved in repair pathways.

In this paper we give a broad overview of the whole DNA repair system and focus on the molecular basis of the repair machineries, particularly in Thermus thermophilus HB8.