Defensins and Sepsis
Joint Authors
Fang, Xiang-Ming
Chen, Qi-Xing
Cheng, Bao-Li
Xie, Guo-Hao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Sepsis is a leading cause of mortality and morbidity in the critical illness.
Multiple immune inflammatory processes take part in the pathogenesis of sepsis.
Defensins are endogenous antimicrobial peptides with three disulphide bonds created by six cysteine residues.
Besides the intrinsic microbicidal properties, defensins are active players which modulate both innate and adaptive immunity against various infections.
Defensins can recruit neutrophils, enhance phagocytosis, chemoattract T cells and dendritic cells, promote complement activation, and induce IL-1β production and pyrotosis.
Previous publications have documented that defensins play important roles in a series of immune inflammatory diseases including sepsis.
This review aims to briefly summarize in vitro, in vivo, and genetic studies on defensins’ effects as well as corresponding mechanisms within sepsis and highlights their promising findings which may be potential targets in future therapies of sepsis.
American Psychological Association (APA)
Xie, Guo-Hao& Chen, Qi-Xing& Cheng, Bao-Li& Fang, Xiang-Ming. 2014. Defensins and Sepsis. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-452284
Modern Language Association (MLA)
Xie, Guo-Hao…[et al.]. Defensins and Sepsis. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-452284
American Medical Association (AMA)
Xie, Guo-Hao& Chen, Qi-Xing& Cheng, Bao-Li& Fang, Xiang-Ming. Defensins and Sepsis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-452284
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452284