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Lasting Developmental Effects of Neonatal Fentanyl Exposure in Preweanling Rats
Joint Authors
Lopes, Maria Francelina
Catré, Dora
Cabrita, António Silvério
Source
Anesthesiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The present study aimed to determine whether neonatal treatment with fentanyl has lasting effects on stressed developing brain.
Six-day-old rats were assigned to one of three groups (10 males/group): (1) fentanyl (incision+fentanyl), (2) saline (incision+0.9% saline), and (3) unoperated (unoperated sham).
Pups with a plantar paw incision received repetitive subcutaneous injections of fentanyl or vehicle through postnatal days (PNDs) 6 to 8.
A nonoperated sham group served as nonstressed control.
Studies included assessment of development from PND 6 to PND 21 (growth indices and behavioral testing).
Fentanyl administered twice daily for three days after surgical incision had no impact on early growth and development, as measured on PND 9, but showed a lasting impact on later growth, enhanced behavioral development, and lower anxiety, as measured through PNDs 10–21.
While this does not completely support a benefit from such treatment, our findings may contribute to support the neonatal use of fentanyl, when indicated, even in premature newborns.
American Psychological Association (APA)
Catré, Dora& Lopes, Maria Francelina& Cabrita, António Silvério. 2011. Lasting Developmental Effects of Neonatal Fentanyl Exposure in Preweanling Rats. Anesthesiology Research and Practice،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-452285
Modern Language Association (MLA)
Catré, Dora…[et al.]. Lasting Developmental Effects of Neonatal Fentanyl Exposure in Preweanling Rats. Anesthesiology Research and Practice No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-452285
American Medical Association (AMA)
Catré, Dora& Lopes, Maria Francelina& Cabrita, António Silvério. Lasting Developmental Effects of Neonatal Fentanyl Exposure in Preweanling Rats. Anesthesiology Research and Practice. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-452285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452285