Gene Expression Profiling in Organ Transplantation
Author
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aim of Review.
Huge effort is being made among the transplant community investigating novel biomarkers that enable transplant clinicians to identify patients at risk for allograft rejection or those who will develop tolerance so that immunosuppression could be safely minimized or even ideally withdrawn.
Despite the important advances achieved in the identification of several potential biomarkers of tolerance, rejection, or both, validation and demonstration of their clinical utility still needs to be tested, which will need international cooperative networks.
It is important to note that the reproducibility of differently expressed genes might be affected by many factors such as gene ranking and selection methods, inherent differences between types, and the choice of thresholds.
However, because microarray analyses are expensive and time consuming and their statistical evaluation is often very difficult, gene expression analysis using the RTPCR method is nowadays recommended.
Conclusions.
In the field of organ transplantation, gene-expression-based decision might help in improving patient and graft outcome and there are a multitude of studies showing that gene-expression profiling is feasible.
American Psychological Association (APA)
Ashry Ahmed Gheith, Osama. 2011. Gene Expression Profiling in Organ Transplantation. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-452295
Modern Language Association (MLA)
Ashry Ahmed Gheith, Osama. Gene Expression Profiling in Organ Transplantation. International Journal of Nephrology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-452295
American Medical Association (AMA)
Ashry Ahmed Gheith, Osama. Gene Expression Profiling in Organ Transplantation. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-452295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452295