The Role of Transforming Growth Factor-Beta in Diabetic Nephropathy
Joint Authors
Fontana Rodrigues, Kathryna
Fernandes, Ana Paula
Braga Gomes, Karina
Source
International Journal of Medical Genetics
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Several studies have demonstrated that chronic and low-grade inflammation is closely linked to type 2 diabetes mellitus.
The associated mechanisms are related to synthesis and release of proinflammatory and anti-inflammatory cytokines, mainly by the adipose tissue.
Moreover, there are evidences that cytokines and adhesion molecules are important for development of diabetic nephropathy.
Among the cytokines associated with inflammatory responses in type 2 diabetes mellitus, the transforming growth factor-β (TGF-β) has been recognized as a central player in the diabetic nephropathy being involved in the development of glomerulosclerosis and interstitial fibrosis, as observed in the course of end-stage renal disease.
Although TGF-β1 is classically an anti-inflammatory immune mediator it has been shown that in the presence of IL-6, which increases before the onset of T2D, TGF-β1 favors the differentiation of T helper 17 (Th17) cells that are activated in many pro-inflammatory conditions.
Since TGF-β1 mRNA and consequently serum TGF-β1 levels are under genetic control, this review aims to discuss the relationship of TGF-β1 levels and polymorphisms in the development of nephropathy in type 2 diabetes mellitus.
American Psychological Association (APA)
Braga Gomes, Karina& Fontana Rodrigues, Kathryna& Fernandes, Ana Paula. 2014. The Role of Transforming Growth Factor-Beta in Diabetic Nephropathy. International Journal of Medical Genetics،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-452304
Modern Language Association (MLA)
Braga Gomes, Karina…[et al.]. The Role of Transforming Growth Factor-Beta in Diabetic Nephropathy. International Journal of Medical Genetics No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-452304
American Medical Association (AMA)
Braga Gomes, Karina& Fontana Rodrigues, Kathryna& Fernandes, Ana Paula. The Role of Transforming Growth Factor-Beta in Diabetic Nephropathy. International Journal of Medical Genetics. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-452304
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452304