Cell Death Mechanisms at the Maternal-Fetal Interface : Insights into the Role of Granulysin
Joint Authors
Veljkovic Vujaklija, Danijela
Gulic, Tamara
Dominovic, Marin
Sucic, Sonja
Rukavina, Daniel
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
During mammal pregnancy, a sensitive balance between hormones, cytokines, humoral factors, and local cellular interactions must be established.
Cytotoxic cells infiltrating the decidua are heavily equipped with cytolytic molecules, in particular perforin and granulysin.
Granulysin is especially abundant in NK cells which are able to spontaneously secrete high quantities of granulysin.
Besides being a potent bactericidal and tumoricidal molecule, granulysin is also found to be a chemoattractant and a proinflammatory molecule.
The precise role(s) of granulysin at the maternal-fetal interface has not been elucidated yet.
It is possible that it behaves as a double-edged sword simultaneously acting as an immunomodulatory and a host defense molecule protecting both the mother and the fetus from a wide spectrum of pathogens, and on the other hand, in case of an NK cell activation, acting as an effector molecule causing the apoptosis of semiallograft trophoblast cells and consequently leading to various pregnancy disorders or pregnancy loss.
American Psychological Association (APA)
Veljkovic Vujaklija, Danijela& Sucic, Sonja& Gulic, Tamara& Dominovic, Marin& Rukavina, Daniel. 2011. Cell Death Mechanisms at the Maternal-Fetal Interface : Insights into the Role of Granulysin. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-452305
Modern Language Association (MLA)
Veljkovic Vujaklija, Danijela…[et al.]. Cell Death Mechanisms at the Maternal-Fetal Interface : Insights into the Role of Granulysin. Clinical and Developmental Immunology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-452305
American Medical Association (AMA)
Veljkovic Vujaklija, Danijela& Sucic, Sonja& Gulic, Tamara& Dominovic, Marin& Rukavina, Daniel. Cell Death Mechanisms at the Maternal-Fetal Interface : Insights into the Role of Granulysin. Clinical and Developmental Immunology. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-452305
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452305