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Aetiology, Clinical Presentation, and Outcome of Meningitis in Patients Coinfected with Human Immunodeficiency Virus and Tuberculosis
Joint Authors
Bhagwan, Smita
Naidoo, Kogieleum
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We conducted a retrospective review of confirmed HIV-TB coinfected patients previously enrolled as part of the SAPiT study in Durban, South Africa.
Patients with suspected meningitis were included in this case series.
From 642 individuals, 14 episodes of meningitis in 10 patients were identified.
For 8 patients, this episode of meningitis was the AIDS defining illness, with cryptococcus (9/14 episodes) and tuberculosis (3/14 episodes) as the commonest aetiological agents.
The combination of headache and neck stiffness (78.6%) was the most frequent clinical presentation.
Relapsing cryptococcal meningitis occurred in 3/7 patients.
Mortality was 70% (7/10), with 4 deaths directly due to meningitis.
In an HIV TB endemic region we identified cryptococcus followed by tuberculosis as the leading causes of meningitis.
We highlight the occurrence of tuberculous meningitis in patients already receiving antituberculous therapy.
The development of meningitis heralded poor outcomes, high mortality, and relapsing meningitis despite ART.
American Psychological Association (APA)
Bhagwan, Smita& Naidoo, Kogieleum. 2011. Aetiology, Clinical Presentation, and Outcome of Meningitis in Patients Coinfected with Human Immunodeficiency Virus and Tuberculosis. AIDS Research and Treatment،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-452310
Modern Language Association (MLA)
Bhagwan, Smita& Naidoo, Kogieleum. Aetiology, Clinical Presentation, and Outcome of Meningitis in Patients Coinfected with Human Immunodeficiency Virus and Tuberculosis. AIDS Research and Treatment No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-452310
American Medical Association (AMA)
Bhagwan, Smita& Naidoo, Kogieleum. Aetiology, Clinical Presentation, and Outcome of Meningitis in Patients Coinfected with Human Immunodeficiency Virus and Tuberculosis. AIDS Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-452310
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452310