The Effects of Helicobacter pylori Eradication on Proteinuria in Patients with Primary Glomerulonephritis
Joint Authors
Ozluk, Yasemin
Kilicaslan, Isin
Sever, Mehmet Sukru
Yazici, Halil
Caliskan, Bahar
Caliskan, Yasar
Turkmen, Aydin
Gulluoglu, Mine
Source
International Journal of Nephrology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Membranous nephropathy (MN) is a common cause of nephrotic syndrome.
In most cases it is idiopathic, while it may also be secondary to many diseases.
In this study, prevalence of H.
pylori infection and the effects of H.
pylori eradication on proteinuria levels were investigated.
Methods.
Thirty five patients with MN (19 male), 12 patients with IgA nephropathy (4 male) and 12 patients with focal segmental glomerulosclerosis (FSGS) (8 male) were studied.
The presence of H.
pylori antigen was investigated in renal tissues obtained by biopsy, and the effects of H.
pylori eradication on proteinuria levels were investigated.
Results.
Immunohistochemistry with H.
pylori antigen revealed no positive staining in the glomeruli of all patients.
19 patients (54%) with MN, 10 (83%) with IgA nephropathy and 4 (33%) with FSGS were positive for H.
pylori stool antigen test (P=0.045).
Patients with H.
pylori infection were administered eradication therapy (lansoprazole, 30 mg twice daily, plus amoxicillin, 0.75 g twice daily, plus clarithromycin, 250 mg twice daily, for 14 days).
Before the eradication therapy the mean proteinuria of patients with MN, IgA nephropathy and FSGS were 2.42 ± 3.24 g/day, 2.12 ± 1.63 g/day and 1.80 ± 1.32 g/day, respectively.
Three months after eradication, baseline proteinuria levels of patients with MN significantly decreased to 1.26 ± 1.73 g/day (P=0.031).
In all three groups there were no significant differences with regard to serum creatinine, albumin and C-reactive protein levels before and after eradication therapy.
Conclusions.
The eradication of H.
pylori infection may be effective to reduce proteinuria in patients with MN, while spontaneous remission of MN could not be excluded in this patient cohort.
This trial is registered with NCT00983034.
American Psychological Association (APA)
Caliskan, Bahar& Yazici, Halil& Caliskan, Yasar& Ozluk, Yasemin& Gulluoglu, Mine& Kilicaslan, Isin…[et al.]. 2014. The Effects of Helicobacter pylori Eradication on Proteinuria in Patients with Primary Glomerulonephritis. International Journal of Nephrology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-452350
Modern Language Association (MLA)
Caliskan, Bahar…[et al.]. The Effects of Helicobacter pylori Eradication on Proteinuria in Patients with Primary Glomerulonephritis. International Journal of Nephrology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-452350
American Medical Association (AMA)
Caliskan, Bahar& Yazici, Halil& Caliskan, Yasar& Ozluk, Yasemin& Gulluoglu, Mine& Kilicaslan, Isin…[et al.]. The Effects of Helicobacter pylori Eradication on Proteinuria in Patients with Primary Glomerulonephritis. International Journal of Nephrology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-452350
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452350