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Sphingosine 1-Phosphate Distribution in Human Plasma : Associations with Lipid Profiles
Joint Authors
al-Gadban, Mohammed M.
Semler, Andrea J.
Klein, Richard L.
Hammad, Samar M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The physiological significance of sphingosine 1-phosphate (S1P) transport in blood has been debated.
We have recently reported a comprehensive sphingolipid profile in human plasma and lipoprotein particles (VLDL, LDL, and HDL) using HPLC-MS/MS (Hammad et al., 2010).
We now determined the relative concentrations of sphingolipids including S1P in the plasma subfraction containing lipoproteins compared to those in the remaining plasma proteins.
Sphingomyelin and ceramide were predominantly recovered in the lipoprotein-containing fraction.
Total plasma S1P concentration was positively correlated with S1P concentration in the protein-containing fraction, but not with S1P concentration in the lipoprotein-containing fraction.
The percentage of S1P transported in plasma lipoproteins was positively correlated with HDL cholesterol (HDL-C) concentration; however, S1P transport in lipoproteins was not limited by the concentration of HDL-C in the individual subject.
Thus, different plasma pools of S1P may have different contributions to S1P signaling in health and disease.
American Psychological Association (APA)
Hammad, Samar M.& al-Gadban, Mohammed M.& Semler, Andrea J.& Klein, Richard L.. 2012. Sphingosine 1-Phosphate Distribution in Human Plasma : Associations with Lipid Profiles. Journal of Lipids،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-452353
Modern Language Association (MLA)
Hammad, Samar M.…[et al.]. Sphingosine 1-Phosphate Distribution in Human Plasma : Associations with Lipid Profiles. Journal of Lipids No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-452353
American Medical Association (AMA)
Hammad, Samar M.& al-Gadban, Mohammed M.& Semler, Andrea J.& Klein, Richard L.. Sphingosine 1-Phosphate Distribution in Human Plasma : Associations with Lipid Profiles. Journal of Lipids. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-452353
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452353