Destroy and Exploit : Catalyzed Removal of Hydroperoxides from the Endoplasmic Reticulum
Joint Authors
Ramming, Thomas
Appenzeller-Herzog, Christian
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-24
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Peroxidases are enzymes that reduce hydroperoxide substrates.
In many cases, hydroperoxide reduction is coupled to the formation of a disulfide bond, which is transferred onto specific acceptor molecules, the so-called reducing substrates.
As such, peroxidases control the spatiotemporal distribution of diffusible second messengers such as hydrogen peroxide (H2O2) and generate new disulfides.
Members of two families of peroxidases, peroxiredoxins (Prxs) and glutathione peroxidases (GPxs), reside in different subcellular compartments or are secreted from cells.
This review discusses the properties and physiological roles of PrxIV, GPx7, and GPx8 in the endoplasmic reticulum (ER) of higher eukaryotic cells where H2O2 and—possibly—lipid hydroperoxides are regularly produced.
Different peroxide sources and reducing substrates for ER peroxidases are critically evaluated.
Peroxidase-catalyzed detoxification of hydroperoxides coupled to the productive use of disulfides, for instance, in the ER-associated process of oxidative protein folding, appears to emerge as a common theme.
Nonetheless, in vitro and in vivo studies have demonstrated that individual peroxidases serve specific, nonoverlapping roles in ER physiology.
American Psychological Association (APA)
Ramming, Thomas& Appenzeller-Herzog, Christian. 2013. Destroy and Exploit : Catalyzed Removal of Hydroperoxides from the Endoplasmic Reticulum. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-452381
Modern Language Association (MLA)
Ramming, Thomas& Appenzeller-Herzog, Christian. Destroy and Exploit : Catalyzed Removal of Hydroperoxides from the Endoplasmic Reticulum. International Journal of Cell Biology No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-452381
American Medical Association (AMA)
Ramming, Thomas& Appenzeller-Herzog, Christian. Destroy and Exploit : Catalyzed Removal of Hydroperoxides from the Endoplasmic Reticulum. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-452381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452381