In Vitro Osteogenic Properties of Two Dental Implant Surfaces
Joint Authors
Monjo, Marta
Lyngstadaas, Staale Petter
Ramis, Joana Maria
Ellingsen, Jan Eirik
Petzold, Christiane
Source
International Journal of Biomaterials
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-15
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Current dental implant research aims at understanding the biological basis for successful implant therapy.
The aim of the study was to perform a full characterization of the effect of two commercial titanium (Ti) surfaces, OsseoSpeed and TiOblast, on the behaviour of mouse preosteoblast MC3T3-E1 cells.
The effect of these Ti surfaces was compared with tissue culture plastic (TCP).
In vitro experiments were performed to evaluate cytotoxicity, cell morphology and proliferation, alkaline phosphatase activity, gene expression, and release of a wide array of osteoblast markers.
No differences were observed on cell viability and cell proliferation.
However, changes were observed in cell shape after 2 days, with a more branched morphology on OsseoSpeed compared to TiOblast.
Moreover, OsseoSpeed surface increased BMP-2 secretion after 2 days, and this was followed by increased IGF-I, BSP, and osterix gene expression and mineralization compared to TiOblast after 14 days.
As compared to the gold standard TCP, both Ti surfaces induced higher osteocalcin and OPG release than TCP and differential temporal gene expression of osteogenic markers.
The results demonstrate that the gain of using OsseoSpeed surface is an improved osteoblast differentiation and mineralization, without additional effects on cell viability or proliferation.
American Psychological Association (APA)
Monjo, Marta& Petzold, Christiane& Ramis, Joana Maria& Lyngstadaas, Staale Petter& Ellingsen, Jan Eirik. 2012. In Vitro Osteogenic Properties of Two Dental Implant Surfaces. International Journal of Biomaterials،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-452388
Modern Language Association (MLA)
Ramis, Joana Maria…[et al.]. In Vitro Osteogenic Properties of Two Dental Implant Surfaces. International Journal of Biomaterials No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-452388
American Medical Association (AMA)
Monjo, Marta& Petzold, Christiane& Ramis, Joana Maria& Lyngstadaas, Staale Petter& Ellingsen, Jan Eirik. In Vitro Osteogenic Properties of Two Dental Implant Surfaces. International Journal of Biomaterials. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-452388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452388