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Flavonoids Inhibit the Respiratory Burst of Neutrophils in Mammals
Joint Authors
Kratchanova, Maria
Denev, Petko
Vasicek, Ondrej
Ambrozova, Gabriela
Lojek, Antonin
Ciz, Milan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Neutrophils represent the front-line defence cells in protecting organisms against infection and play an irreplaceable role in the proper performance of the immune system.
As early as within the first minutes of stimulation, neutrophilic NADPH oxidase is activated, and cells release large quantities of highly toxic reactive oxygen species (ROS).
These oxidants can be highly toxic not only for infectious agents but also for neighboring host tissues.
Since flavonoids exhibit antioxidant and anti-inflammatory effects, they are subjects of interest for pharmacological modulation of ROS production.
The present paper summarizes contemporary knowledge on the effects of various flavonoids on the respiratory burst of mammalian neutrophils.
It can be summarized that the inhibitory effects of flavonoids on the respiratory burst of phagocytes are mediated via inhibition of enzymes involved in cell signaling as well as via modulation of redox status.
However, the effects of flavonoids are even more complex, and several sites of action, depending upon the flavonoid structure and way of application, are included.
American Psychological Association (APA)
Ciz, Milan& Denev, Petko& Kratchanova, Maria& Vasicek, Ondrej& Ambrozova, Gabriela& Lojek, Antonin. 2012. Flavonoids Inhibit the Respiratory Burst of Neutrophils in Mammals. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-452412
Modern Language Association (MLA)
Ciz, Milan…[et al.]. Flavonoids Inhibit the Respiratory Burst of Neutrophils in Mammals. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-452412
American Medical Association (AMA)
Ciz, Milan& Denev, Petko& Kratchanova, Maria& Vasicek, Ondrej& Ambrozova, Gabriela& Lojek, Antonin. Flavonoids Inhibit the Respiratory Burst of Neutrophils in Mammals. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-452412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452412