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The Emerging Role of TLR and Innate Immunity in Cardiovascular Disease
Joint Authors
Shaw, Sidney G.
Spirig, Rolf
Tsui, Janice C. S.
Source
Cardiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cardiovascular disease is a complex disorder involving multiple pathophysiological processes, several of which involve activation of toll-like receptors (TLRs) of the innate immune system.
As sentinels of innate immunity TLRs are nonclonally germline-encoded molecular pattern recognition receptors that recognize exogenous as well as tissue-derived molecular dangers signals promoting inflammation.
In addition to their expression in immune cells, TLRs are found in other tissues and cell types including cardiomyocytes, endothelial and vascular smooth muscle cells.
TLRs are differentially regulated in various cell types by several cardiovascular risk factors such as hypercholesterolemia, hyperlipidemia, and hyperglycemia and may represent a key mechanism linking chronic inflammation, cardiovascular disease progression, and activation of the immune system.
Modulation of TLR signaling by specific TLR agonists or antagonists, alone or in combination, may be a useful therapeutic approach to treat various cardiovascular inflammatory conditions such as atherosclerosis, peripheral arterial disease, secondary microvascular complications of diabetes, autoimmune disease, and ischemia reperfusion injury.
In this paper we discuss recent developments and current evidence for the role of TLR in cardiovascular disease as well as the therapeutic potential of various compounds on inhibition of TLR-mediated inflammatory responses.
American Psychological Association (APA)
Spirig, Rolf& Tsui, Janice C. S.& Shaw, Sidney G.. 2012. The Emerging Role of TLR and Innate Immunity in Cardiovascular Disease. Cardiology Research and Practice،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-452419
Modern Language Association (MLA)
Spirig, Rolf…[et al.]. The Emerging Role of TLR and Innate Immunity in Cardiovascular Disease. Cardiology Research and Practice No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-452419
American Medical Association (AMA)
Spirig, Rolf& Tsui, Janice C. S.& Shaw, Sidney G.. The Emerging Role of TLR and Innate Immunity in Cardiovascular Disease. Cardiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-452419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452419