An Overview on the Field of Micro- and Nanotechnologies for Synthetic Peptide-Based Vaccines
Joint Authors
Pedraz, José Luis
Salvador, Aiala
Igartua, Manoli
Hernández, Rosa Maria
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-15
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The development of synthetic peptide-based vaccines has many advantages in comparison with vaccines based on live attenuated organisms, inactivated or killed organism, or toxins.
Peptide-based vaccines cannot revert to a virulent form, allow a better conservation, and are produced more easily and safely.
However, they generate a weaker immune response than other vaccines, and the inclusion of adjuvants and/or the use of vaccine delivery systems is almost always needed.
Among vaccine delivery systems, micro- and nanoparticulated ones are attractive, because their particulate nature can increase cross-presentation of the peptide.
In addition, they can be passively or actively targeted to antigen presenting cells.
Furthermore, particulate adjuvants are able to directly activate innate immune system in vivo.
Here, we summarize micro- and nanoparticulated vaccine delivery systems used in the field of synthetic peptide-based vaccines as well as strategies to increase their immunogenicity.
American Psychological Association (APA)
Salvador, Aiala& Igartua, Manoli& Hernández, Rosa Maria& Pedraz, José Luis. 2011. An Overview on the Field of Micro- and Nanotechnologies for Synthetic Peptide-Based Vaccines. Journal of Drug Delivery،Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-452436
Modern Language Association (MLA)
Salvador, Aiala…[et al.]. An Overview on the Field of Micro- and Nanotechnologies for Synthetic Peptide-Based Vaccines. Journal of Drug Delivery No. 2011 (2011), pp.1-18.
https://search.emarefa.net/detail/BIM-452436
American Medical Association (AMA)
Salvador, Aiala& Igartua, Manoli& Hernández, Rosa Maria& Pedraz, José Luis. An Overview on the Field of Micro- and Nanotechnologies for Synthetic Peptide-Based Vaccines. Journal of Drug Delivery. 2011. Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-452436
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452436