Synthesis and Antimicrobial Evaluation of a New Series of N-1,3-Benzothiazol-2-ylbenzamides

Abstract EN

Enterococcus faecalis is a Gram-positive commensal inhabitant of the intestinal tract of humans, animals, and insects.

However, it is also an opportunistic pathogen and has emerged as a leading cause of hospital-acquired extraintestinal infections.

Fluoroquinolones have been frequently used to treat E.

faecalis infections, and the emergence of fluoroquinolone-resistant E.

faecalis strains has recently been reported in several countries.

Thus, the identifications of new antibiotics specifically directed to E.

faecalis may be envisaged.

In this paper, a new series of N-1,3-benzothiazol-2-ylbenzamides have been designed, synthesized, and evaluated for their in vitro antimicrobial activities.

Among the tested compounds, 3i was active against E.

faecalis.