Interleukin-4 in the Generation of the AERD Phenotype : Implications for Molecular Mechanisms Driving Therapeutic Benefit of Aspirin Desensitization
Joint Authors
Payne, Spencer C.
Borish, Larry
Steinke, John W.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aspirin-exacerbated respiratory disease (AERD) is explained in part by over-expression of 5-lipoxygenase, leukotriene C4 synthase (LTC4S) and the cysteinyl leukotriene (CysLT) receptors (CysLT1 and 2), resulting in constitutive over-production of CysLTs and the hyperresponsiveness to CysLTs that occurs with aspirin ingestion.
Increased levels of IL-4 have been found in the sinus mucosa and nasal polyps of AERD subjects.
Previous studies demonstrated that IL-4 is primarily responsible for the upregulation of LTC4S by mast cells and the upregulation of CysLT1 and 2 receptors on many immune cell types.
Prostaglandin E2 (PGE2) acts to prevent CysLT secretion by inhibiting mast cell and eosinophil activation.
PGE2 concentrations are reduced in AERD reflecting diminished expression of cyclooxygenase (COX)-2.
IL-4 can inhibit basal and stimulated expression of COX-2 and microsomal PGE synthase 1 leading to decreased capacity for PGE2 secretion.
Thus, IL-4 plays an important pathogenic role in generating the phenotype of AERD.
This review will examine the evidence supporting this hypothesis and describe a model of how aspirin desensitization provides therapeutic benefit for AERD patients.
American Psychological Association (APA)
Steinke, John W.& Payne, Spencer C.& Borish, Larry. 2012. Interleukin-4 in the Generation of the AERD Phenotype : Implications for Molecular Mechanisms Driving Therapeutic Benefit of Aspirin Desensitization. Journal of Allergy،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-452479
Modern Language Association (MLA)
Steinke, John W.…[et al.]. Interleukin-4 in the Generation of the AERD Phenotype : Implications for Molecular Mechanisms Driving Therapeutic Benefit of Aspirin Desensitization. Journal of Allergy No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-452479
American Medical Association (AMA)
Steinke, John W.& Payne, Spencer C.& Borish, Larry. Interleukin-4 in the Generation of the AERD Phenotype : Implications for Molecular Mechanisms Driving Therapeutic Benefit of Aspirin Desensitization. Journal of Allergy. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-452479
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452479