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Large-Scale Modeling of Epileptic Seizures : Scaling Properties of Two Parallel Neuronal Network Simulation Algorithms
Joint Authors
van Drongelen, Wim
Pesce, Lorenzo L.
Visser, Sid
Hereld, Mark
Stevens, Rick L.
Wildeman, Albert
Lee, Hyong C.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Our limited understanding of the relationship between the behavior of individual neurons and large neuronal networks is an important limitation in current epilepsy research and may be one of the main causes of our inadequate ability to treat it.
Addressing this problem directly via experiments is impossibly complex; thus, we have been developing and studying medium-large-scale simulations of detailed neuronal networks to guide us.
Flexibility in the connection schemas and a complete description of the cortical tissue seem necessary for this purpose.
In this paper we examine some of the basic issues encountered in these multiscale simulations.
We have determined the detailed behavior of two such simulators on parallel computer systems.
The observed memory and computation-time scaling behavior for a distributed memory implementation were very good over the range studied, both in terms of network sizes (2,000 to 400,000 neurons) and processor pool sizes (1 to 256 processors).
Our simulations required between a few megabytes and about 150 gigabytes of RAM and lasted between a few minutes and about a week, well within the capability of most multinode clusters.
Therefore, simulations of epileptic seizures on networks with millions of cells should be feasible on current supercomputers.
American Psychological Association (APA)
Pesce, Lorenzo L.& Lee, Hyong C.& Hereld, Mark& Visser, Sid& Stevens, Rick L.& Wildeman, Albert…[et al.]. 2013. Large-Scale Modeling of Epileptic Seizures : Scaling Properties of Two Parallel Neuronal Network Simulation Algorithms. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-452483
Modern Language Association (MLA)
Pesce, Lorenzo L.…[et al.]. Large-Scale Modeling of Epileptic Seizures : Scaling Properties of Two Parallel Neuronal Network Simulation Algorithms. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-452483
American Medical Association (AMA)
Pesce, Lorenzo L.& Lee, Hyong C.& Hereld, Mark& Visser, Sid& Stevens, Rick L.& Wildeman, Albert…[et al.]. Large-Scale Modeling of Epileptic Seizures : Scaling Properties of Two Parallel Neuronal Network Simulation Algorithms. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-452483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452483