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Pegylated Gold Nanoparticles Induce Apoptosis in Human Chronic Myeloid Leukemia Cells
Joint Authors
Yang, Yuh-Cheng
Wang, Tao-Yeuan
Yang, Kai-Chien
Shieh, Hui-Ru
Hwu, Yeukuang
Huang, Yu-Chuen
Chen, Yu-Jen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Gold nanoparticles (AuNPs) have several potential biological applications as well as excellent biocompatibility.
AuNPs with surface modification using polyethylene glycol (PEG-AuNPs) can facilitate easy conjugation with various biological molecules of interest.
To examine the anticancer bioactivity of PEG-AuNPs, we investigated their effect on human chronic myeloid leukemia K562 cells.
The results indicated that PEG-AuNPs markedly inhibited the viability and impaired the cell membrane integrity of K562 cells.
The particles caused morphological changes typical of cell death, and a marked increase in the sub-G1 population in DNA histogram, indicating apoptosis.
In addition, PEG-AuNPs reduced the mitochondrial transmembrane potential, a hallmark of the involvement of intrinsic apoptotic pathway in K562 cells.
Observation of ultrastructure under a transmission electron microscope revealed that the internalized PEG-AuNPs were distributed into cytoplasmic vacuoles and damaged mitochondria, and subsequently accumulated in areas surrounding the nuclear membrane.
In conclusion, PEG-AuNPs may have the potential to inhibit growth and induce apoptosis in human chronic myeloid leukemia cells.
American Psychological Association (APA)
Huang, Yu-Chuen& Yang, Yuh-Cheng& Yang, Kai-Chien& Shieh, Hui-Ru& Wang, Tao-Yeuan& Hwu, Yeukuang…[et al.]. 2014. Pegylated Gold Nanoparticles Induce Apoptosis in Human Chronic Myeloid Leukemia Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-452496
Modern Language Association (MLA)
Huang, Yu-Chuen…[et al.]. Pegylated Gold Nanoparticles Induce Apoptosis in Human Chronic Myeloid Leukemia Cells. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-452496
American Medical Association (AMA)
Huang, Yu-Chuen& Yang, Yuh-Cheng& Yang, Kai-Chien& Shieh, Hui-Ru& Wang, Tao-Yeuan& Hwu, Yeukuang…[et al.]. Pegylated Gold Nanoparticles Induce Apoptosis in Human Chronic Myeloid Leukemia Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-452496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452496