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Medullary Thyroid Carcinoma : Targeted Therapies and Future Directions
Joint Authors
Chen, Herbert
Pinchot, Scott N.
Kunnimalaiyaan, Muthusamy
Sippel, Rebecca S.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Medullary thyroid cancer (MTC) is a rare neuroendocrine neoplasm that accounts for approximately 5% of all thyroid malignancies.
The natural history of MTC is characterized by early lymph node and distant metastases, making complete surgical cure often impossible.
Conventional chemotherapy and external beam radiation have been largely ineffective in altering the natural history of MTC.
Therefore, there is a great need to develop novel therapeutic strategies to affect symptom control and reduce tumor burden in patients with widely disseminated disease.
Here, we review several pathways which have been shown to be vital in MTC tumorigenesis and focus on the pathways of interest for which targeted drug therapies are currently being developed.
American Psychological Association (APA)
Pinchot, Scott N.& Kunnimalaiyaan, Muthusamy& Sippel, Rebecca S.& Chen, Herbert. 2009. Medullary Thyroid Carcinoma : Targeted Therapies and Future Directions. Journal of Oncology،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-452556
Modern Language Association (MLA)
Pinchot, Scott N.…[et al.]. Medullary Thyroid Carcinoma : Targeted Therapies and Future Directions. Journal of Oncology No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-452556
American Medical Association (AMA)
Pinchot, Scott N.& Kunnimalaiyaan, Muthusamy& Sippel, Rebecca S.& Chen, Herbert. Medullary Thyroid Carcinoma : Targeted Therapies and Future Directions. Journal of Oncology. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-452556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452556