Synthesis and Microbial Activity of Novel 3-Methyl-2-pyrazolin-5-one Derivatives
Joint Authors
Alothman, Othman Y.
Mostafa, Mohamed S.
Abd El-Salam, Nasser M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
2-Oxo-2H-chromene-3-carbohydrazide derivatives 2a,b react with 2-{[4-(substituted thiazol-2-yl)iminoethyl)-phenyl]hydrazono}-3-oxo-butyric acid ethyl esters 4a–c to give 3-methyl-1-[(2-oxo-2H-chromen-3-yl) carbonyl]-4-{[4-(substituted thiazol-2-yl)iminoethyl)-phenyl]hydrazono}]-2-pyrazolin-5-one derivatives 5a–f.
A considerable increase in the reaction rate had been observed with better yield using microwave irradiation for the synthesis of compounds 2a, b, 3a–c, and 5a–f.
The synthesized products were tested against B.
subtilis, S.
aureus, and E.
coli as well as C.
albicans compared with tetracycline and nystatin as reference drugs.
American Psychological Association (APA)
Mostafa, Mohamed S.& Abd El-Salam, Nasser M.& Alothman, Othman Y.. 2013. Synthesis and Microbial Activity of Novel 3-Methyl-2-pyrazolin-5-one Derivatives. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-452569
Modern Language Association (MLA)
Mostafa, Mohamed S.…[et al.]. Synthesis and Microbial Activity of Novel 3-Methyl-2-pyrazolin-5-one Derivatives. Journal of Chemistry No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-452569
American Medical Association (AMA)
Mostafa, Mohamed S.& Abd El-Salam, Nasser M.& Alothman, Othman Y.. Synthesis and Microbial Activity of Novel 3-Methyl-2-pyrazolin-5-one Derivatives. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-452569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452569