Fear-Potentiated Behaviour Is Modulated by Central Amygdala Angiotensin II AT1 Receptors Stimulation
Joint Authors
Bregonzio, Claudia
Casarsa, Brenda S.
Pérez, Pablo A.
Baiardi, Gustavo
Gargiulo, Pascual A.
Marinzalda, Maria de los Angeles
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Central nucleus of the amygdala (CeA) is one of the most important regulatory centres for the emotional processes.
Among the different neurotransmitter systems present in this nucleus, AT1 receptors have been also found, but their role in the generation and modulation of emotions is not fully understood.
The present work evaluated the effect of intra-amygdalar injection of losartan (AT1 receptor antagonist) and angiotensin II (Ang II) in the anxiety state induced by fear-potentiated plus maze in male Wistar rats.
Fear in the elevated plus maze can be potentiated by prior inescapable footshock stress.
The decrease in the time spent in the open arms induced by the inescapable footshock was totally prevented by losartan (4 pmol) administration in CeA.
It was also found that Ang II (48 fmol) administration decreased the time spent in the open arms in animals with or without previous footshock exposure.
The locomotor activity and grooming behaviour were also evaluated.
The results obtained from the different parameters analyzed allowed us to conclude that the Ang II AT1 receptors in CeA are involved in the anxiety state induced by stress in the fear-potentiated plus-maze behaviour.
American Psychological Association (APA)
Marinzalda, Maria de los Angeles& Pérez, Pablo A.& Gargiulo, Pascual A.& Casarsa, Brenda S.& Bregonzio, Claudia& Baiardi, Gustavo. 2014. Fear-Potentiated Behaviour Is Modulated by Central Amygdala Angiotensin II AT1 Receptors Stimulation. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-452580
Modern Language Association (MLA)
Marinzalda, Maria de los Angeles…[et al.]. Fear-Potentiated Behaviour Is Modulated by Central Amygdala Angiotensin II AT1 Receptors Stimulation. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-452580
American Medical Association (AMA)
Marinzalda, Maria de los Angeles& Pérez, Pablo A.& Gargiulo, Pascual A.& Casarsa, Brenda S.& Bregonzio, Claudia& Baiardi, Gustavo. Fear-Potentiated Behaviour Is Modulated by Central Amygdala Angiotensin II AT1 Receptors Stimulation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-452580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452580