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Multiple Myeloma Macrophages : Pivotal Players in the Tumor Microenvironment
Joint Authors
Catacchio, Ivana
Vacca, Angelo
Ria, Roberto
Moschetta, Michele
Reale, Antonia
De Luisi, Annunziata
Berardi, Simona
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Tumor microenvironment is essential for multiple myeloma (MM) growth, progression, and drug resistance through provision of survival signals and secretion of growth and proangiogenic factors.
This paper examines the importance of macrophages within MM bone marrow (BM) microenvironment, referred to as MM-associated macrophages, as a potential niche component that supports tumor plasma cells.
These macrophages are derived from peripheral blood monocytes recruited into the tumor.
Upon activation by MM plasma cells and mesenchymal stromal cells, macrophages can release growth factors, proteolytic enzymes, cytokines, and inflammatory mediators that promote plasma cell growth and survival.
Macrophages promote tumor progression through several mechanisms including angiogenesis, growth, and drug resistance.
Indeed, these macrophages are essential for the induction of an angiogenic response through vasculogenic mimicry, and this ability proceeds in step with progression of the plasma cell tumors.
Data suggest that macrophages play an important role in the biology and survival of patients with MM, and they may be a target for the MM antivascular management.
American Psychological Association (APA)
Berardi, Simona& Ria, Roberto& Reale, Antonia& De Luisi, Annunziata& Catacchio, Ivana& Moschetta, Michele…[et al.]. 2013. Multiple Myeloma Macrophages : Pivotal Players in the Tumor Microenvironment. Journal of Oncology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-452610
Modern Language Association (MLA)
Berardi, Simona…[et al.]. Multiple Myeloma Macrophages : Pivotal Players in the Tumor Microenvironment. Journal of Oncology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-452610
American Medical Association (AMA)
Berardi, Simona& Ria, Roberto& Reale, Antonia& De Luisi, Annunziata& Catacchio, Ivana& Moschetta, Michele…[et al.]. Multiple Myeloma Macrophages : Pivotal Players in the Tumor Microenvironment. Journal of Oncology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-452610
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452610