Neoadjuvant Therapy in Pancreatic Cancer : An Emerging Strategy
Joint Authors
Santoni, Matteo
Andrikou, Kalliopi
Pellei, Chiara
Bittoni, Alessandro
Lanese, Andrea
Stefano, Cascinu
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Pancreatic adenocarcinoma (PDAC) is the fourth leading cause of cancer deaths among men and women, being responsible for 6% of all cancer-related deaths.
Surgical resection offers the only chance of cure, but only 15 to 20 percent of cases are potentially resectable at presentation.
In recent years, increasing evidences support the use of neoadjuvant strategies in pancreatic cancer in patients with resectable pancreatic cancer as well as in patients with borderline resectable or locally advanced PDAC in order to allow early treatment of micrometastatic disease, tumour regression, and reduced risk of peritoneal tumour implantation during surgery.
Furthermore, neoadjuvant treatment allows evaluation of tumour response and increases patient’s compliance.
However, most evidences in this setting come from retrospective analysis or small case series and in many studies chemotherapy or chemoradiation therapies used were suboptimal.
Currently, prospective randomized trials using the most active chemotherapy regimens available are trying to define the real benefit of neoadjuvant strategies compared to conventional adjuvant strategies.
In this review, the authors examined available data on neoadjuvant treatment in patients with resectable pancreatic cancer as well as in patients with borderline resectable or locally advanced PDAC and the future directions in this peculiar setting.
American Psychological Association (APA)
Bittoni, Alessandro& Santoni, Matteo& Lanese, Andrea& Pellei, Chiara& Andrikou, Kalliopi& Stefano, Cascinu. 2014. Neoadjuvant Therapy in Pancreatic Cancer : An Emerging Strategy. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-452637
Modern Language Association (MLA)
Bittoni, Alessandro…[et al.]. Neoadjuvant Therapy in Pancreatic Cancer : An Emerging Strategy. Gastroenterology Research and Practice No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-452637
American Medical Association (AMA)
Bittoni, Alessandro& Santoni, Matteo& Lanese, Andrea& Pellei, Chiara& Andrikou, Kalliopi& Stefano, Cascinu. Neoadjuvant Therapy in Pancreatic Cancer : An Emerging Strategy. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-452637
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452637