Simulation of Arrhythmogenic Effect of Rogue RyRs in Failing Heart by Using a Coupled Model
Joint Authors
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cardiac cells with heart failure are usually characterized by impairment of Ca2+ handling with smaller SR Ca2+ store and high risk of triggered activities.
In this study, we developed a coupled model by integrating the spatiotemporal Ca2+ reaction-diffusion system into the cellular electrophysiological model.
With the coupled model, the subcellular Ca2+ dynamics and global cellular electrophysiology could be simultaneously traced.
The proposed coupled model was then applied to study the effects of rogue RyRs on Ca2+ cycling and membrane potential in failing heart.
The simulation results suggested that, in the presence of rogue RyRs, Ca2+ dynamics is unstable and Ca2+ waves are prone to be initiated spontaneously.
These release events would elevate the membrane potential substantially which might induce delayed afterdepolarizations or triggered action potentials.
Moreover, the variation of membrane potential depolarization is indicated to be dependent on the distribution density of rogue RyR channels.
This study provides a new possible arrhythmogenic mechanism for heart failure from subcellular to cellular level.
American Psychological Association (APA)
Lu, Luyao& Xia, Ling& Zhu, Xiuwei. 2012. Simulation of Arrhythmogenic Effect of Rogue RyRs in Failing Heart by Using a Coupled Model. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-452648
Modern Language Association (MLA)
Lu, Luyao…[et al.]. Simulation of Arrhythmogenic Effect of Rogue RyRs in Failing Heart by Using a Coupled Model. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-452648
American Medical Association (AMA)
Lu, Luyao& Xia, Ling& Zhu, Xiuwei. Simulation of Arrhythmogenic Effect of Rogue RyRs in Failing Heart by Using a Coupled Model. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-452648
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452648