Dyslipidemia and Blood-Brain Barrier Integrity in Alzheimer's Disease
Joint Authors
Bowman, Gene L.
Kaye, Jeffrey A.
Quinn, Joseph F.
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Blood-brain barrier (BBB) dysfunction may have a significant role in the pathogenesis of Alzheimer's disease (AD).
Modifiable factors associated with BBB function may have therapeutic implication.
This study tested the hypothesis that dyslipidemia is associated with BBB impairment in mild-to-moderate AD.
Methods.
Thirty-six subjects with AD were followed for 1 year.
Fasting CSF and plasma were collected with clinical assessments at baseline and 12 months.
BBB impairment was defined as CSF albumin index ≥9.
Independent t-tests and linear regression assessed the relationship between plasma lipoproteins and BBB integrity.
Results.
Dyslipidemia was prevalent in 47% of the population, and in 75% of those with BBB impairment.
Subjects with BBB impairment had significantly higher mean plasma triglyceride and lower HDL cholesterol (TG, P=0.007; HDL, P=0.043).
Plasma triglycerides explained 22% of the variance in BBB integrity and remained significant after controlling for age, gender, ApoE-4 genotype, blood pressure, and statin use.
Conclusion.
Dyslipidemia is more prevalent in AD subjects with BBB impairment.
Plasma triglyceride and HDL cholesterol may have a role in maintaining BBB integrity in mild-to-moderate Alzheimer's disease.
American Psychological Association (APA)
Bowman, Gene L.& Kaye, Jeffrey A.& Quinn, Joseph F.. 2012. Dyslipidemia and Blood-Brain Barrier Integrity in Alzheimer's Disease. Current Gerontology and Geriatrics Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-452654
Modern Language Association (MLA)
Bowman, Gene L.…[et al.]. Dyslipidemia and Blood-Brain Barrier Integrity in Alzheimer's Disease. Current Gerontology and Geriatrics Research No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-452654
American Medical Association (AMA)
Bowman, Gene L.& Kaye, Jeffrey A.& Quinn, Joseph F.. Dyslipidemia and Blood-Brain Barrier Integrity in Alzheimer's Disease. Current Gerontology and Geriatrics Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-452654
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452654