Urinary Metabolomics on the Biochemical Profiles in Diet-Induced Hyperlipidemia Rat Using Ultraperformance Liquid Chromatography Coupled with Quadrupole Time-of-Flight SYNAPT High-Definition Mass Spectrometry
Joint Authors
Chen, Hua
Miao, Hua
Fang, Min-Feng
Yin, Lu
Chen, Dan-Qian
Wei, Feng
Cheng, Xian-Long
Bai, Xu
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ultraperformance liquid chromatography coupled with quadrupole time-of-flight synapt high-definition mass spectrometry metabolomics was used to characterize the urinary metabolic profiling of diet-induced hyperlipidaemia in a rat model.
Analysis was done by orthogonal partial least squares discriminant analysis, correlation analysis, heat map analysis, and KEGG pathways analysis.
Potential biomarkers were chosen by S-plot and were identified by accurate mass, isotopic pattern, and MS/MS fragments information.
Significant differences in fatty acid, amino acid, nucleoside, and bile acid were observed, indicating the perturbations of fatty acid, amino acid, nucleoside, and bile acid metabolisms in diet-induced hyperlipidaemia rats.
This study provides further insight into the metabolic profiling across a wide range of biochemical pathways in response to diet-induced hyperlipidaemia.
American Psychological Association (APA)
Miao, Hua& Chen, Hua& Fang, Min-Feng& Yin, Lu& Chen, Dan-Qian& Cheng, Xian-Long…[et al.]. 2014. Urinary Metabolomics on the Biochemical Profiles in Diet-Induced Hyperlipidemia Rat Using Ultraperformance Liquid Chromatography Coupled with Quadrupole Time-of-Flight SYNAPT High-Definition Mass Spectrometry. Journal of Analytical Methods in Chemistry،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-452668
Modern Language Association (MLA)
Miao, Hua…[et al.]. Urinary Metabolomics on the Biochemical Profiles in Diet-Induced Hyperlipidemia Rat Using Ultraperformance Liquid Chromatography Coupled with Quadrupole Time-of-Flight SYNAPT High-Definition Mass Spectrometry. Journal of Analytical Methods in Chemistry No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-452668
American Medical Association (AMA)
Miao, Hua& Chen, Hua& Fang, Min-Feng& Yin, Lu& Chen, Dan-Qian& Cheng, Xian-Long…[et al.]. Urinary Metabolomics on the Biochemical Profiles in Diet-Induced Hyperlipidemia Rat Using Ultraperformance Liquid Chromatography Coupled with Quadrupole Time-of-Flight SYNAPT High-Definition Mass Spectrometry. Journal of Analytical Methods in Chemistry. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-452668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452668