![](/images/graphics-bg.png)
Progress towards Mechanism-Based Treatment for Diamond-Blackfan Anemia
Joint Authors
Flygare, Johan
Sjögren, Sara E.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplastic anemia, characterized by macrocytic anemia, reticulocytopenia, and severely reduced numbers of erythroid precursors in the bone marrow.
For more than fifty years, glucocorticoids have remained the main option for pharmacological treatment of DBA.
While continuous glucocorticoid administration increases hemoglobin levels in a majority of DBA patients, it also causes severe side effects.
There is therefore a great need for more specific and effective treatments to boost or replace the use of glucocorticoids.
Over the years, many alternative therapies have been tried out, but most of them have shown to be ineffective.
Here we review previous and current attempts to develop such alternative therapies for DBA.
We further discuss how emerging knowledge regarding the pathological mechanism in DBA and the therapeutic mechanism of glucocorticoids treatment may reveal novel drug targets for DBA treatment.
American Psychological Association (APA)
Sjögren, Sara E.& Flygare, Johan. 2012. Progress towards Mechanism-Based Treatment for Diamond-Blackfan Anemia. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-452686
Modern Language Association (MLA)
Sjögren, Sara E.& Flygare, Johan. Progress towards Mechanism-Based Treatment for Diamond-Blackfan Anemia. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-452686
American Medical Association (AMA)
Sjögren, Sara E.& Flygare, Johan. Progress towards Mechanism-Based Treatment for Diamond-Blackfan Anemia. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-452686
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452686