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Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain
Joint Authors
Wu, Runjie
Tao, Weiwei
Zhou, Xin
Ge, Xiaoyin
Wang, Yuyue
Wu, Haoxin
Xue, Wenda
Chen, Gang
Jiang, Lihua
Wang, Dan
Yi, Nan
Jiang, Jingjing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The traditional antidepressants have a major disadvantage in delayed onset of efficacy, and the emerging fast-acting antidepressant ketamine has adverse behavioral and neurotoxic effects.
Yueju pill, an herb medicine formulated eight hundred years ago by Doctor Zhu Danxi, has been popularly prescribed in China for alleviation of depression-like symptoms.
Although several clinical outcome studies reported the relative short onset of antidepressant effects of Yueju, this has not been scientifically investigated.
We, therefore, examined the rapid antidepressant effect of Yueju in mice and tested the underlying molecular mechanisms.
We found that acute administration of ethanol extract of Yueju rapidly attenuated depressive-like symptoms in learned helpless paradigm, and the antidepressant-like effects were sustained for at least 24 hours in tail suspension test in ICR mice.
Additionally, Yueju, like ketamine, rapidly increased the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus, whereas the BDNF mRNA expression remained unaltered.
Yueju rapidly reduced the phosphorylation of eukaryotic elongation factor 2 (eEF2), leading to desuppression of BDNF synthesis.
Unlike ketamine, both the BDNF expression and eEF2 phosphorylation were revered at 24 hours after Yueju administration.
This study is the first to demonstrate the rapid antidepressant effects of an herb medicine, offering an opportunity to improve therapy of depression.
American Psychological Association (APA)
Xue, Wenda& Zhou, Xin& Yi, Nan& Jiang, Lihua& Tao, Weiwei& Wu, Runjie…[et al.]. 2013. Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-452687
Modern Language Association (MLA)
Xue, Wenda…[et al.]. Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-452687
American Medical Association (AMA)
Xue, Wenda& Zhou, Xin& Yi, Nan& Jiang, Lihua& Tao, Weiwei& Wu, Runjie…[et al.]. Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-452687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452687