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The Role of Nrf2 : Adipocyte Differentiation, Obesity, and Insulin Resistance
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Metabolic diseases, such as type 2 diabetes and obesity, are increasing globally, and much work has been performed to elucidate the regulatory mechanisms of these diseases.
Nuclear factor E2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor that serves as a primary cellular defense against the cytotoxic effects of oxidative stress.
Recent studies have proposed a close relationship between oxidative stress and energy metabolism-associated disease.
The Nrf2 pathway, as a master regulator of cellular defense against oxidative stress, has emerged as a critical target of energy metabolism; however, its effects are controversial.
This review examines the current state of research on the role of Nrf2 on energy metabolism, specifically with respect to its participation in adipocyte differentiation, obesity, and insulin resistance, and discusses the possibility of using Nrf2 as a therapeutic target in the clinic.
American Psychological Association (APA)
Seo, Hyun-Ae& Lee, In-Kyu. 2013. The Role of Nrf2 : Adipocyte Differentiation, Obesity, and Insulin Resistance. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-452698
Modern Language Association (MLA)
Seo, Hyun-Ae& Lee, In-Kyu. The Role of Nrf2 : Adipocyte Differentiation, Obesity, and Insulin Resistance. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-452698
American Medical Association (AMA)
Seo, Hyun-Ae& Lee, In-Kyu. The Role of Nrf2 : Adipocyte Differentiation, Obesity, and Insulin Resistance. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-452698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452698