IL1RN and KRT13 Expression in Bladder Cancer : Association with Pathologic Characteristics and Smoking Status
Joint Authors
Weiß, Christel
Gabriel, Ute
Worst, Thomas S.
Martini, Thomas
Reiner, Verena
Erben, Philipp
Bolenz, Christian
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
To validate microarray data on cytokeratin 13 (KRT13) and interleukin-1 receptor antagonist (IL1RN) expression in urothelial carcinoma of the urinary bladder (UCB) and to correlate our findings with pathologic characteristics and tobacco smoking.
Methods.
UCB tissue samples (n=109) and control samples (n=14) were obtained from transurethral resection and radical cystectomy specimens.
Immunohistochemical staining of KRT13 and IL1RN was performed and semiquantitative expression scores were assessed.
Smoking status was evaluated using a standardized questionnaire.
Expression scores were correlated with pathologic characteristics (tumor stage and grade) and with smoking status.
Results.
Loss of KRT13 and IL1RN expression was observed in UCB tissue samples when compared to controls (P=0.007, P=0.008) in which KRT13 and IL1RN expression were high.
IL1RN expression was significantly reduced in muscle-invasive tumors (P=0.003).
In tissue samples of current smokers, a significant downregulation of IL1RN was found when compared to never smokers (P=0.013).
Conclusion.
Decreased expressions of KRT13 and IL1RN are common features of UCB and are associated with aggressive disease.
Tobacco smoking may enhance the loss of IL1RN, indicating an overweight of proinflammatory mediators involved in UCB progression.
Further validation of the influence of smoking on IL1RN expression is warranted.
American Psychological Association (APA)
Worst, Thomas S.& Reiner, Verena& Gabriel, Ute& Weiß, Christel& Erben, Philipp& Martini, Thomas…[et al.]. 2014. IL1RN and KRT13 Expression in Bladder Cancer : Association with Pathologic Characteristics and Smoking Status. Advances in Urology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-452699
Modern Language Association (MLA)
Worst, Thomas S.…[et al.]. IL1RN and KRT13 Expression in Bladder Cancer : Association with Pathologic Characteristics and Smoking Status. Advances in Urology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-452699
American Medical Association (AMA)
Worst, Thomas S.& Reiner, Verena& Gabriel, Ute& Weiß, Christel& Erben, Philipp& Martini, Thomas…[et al.]. IL1RN and KRT13 Expression in Bladder Cancer : Association with Pathologic Characteristics and Smoking Status. Advances in Urology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-452699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452699