Investigation of Association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of Butyrylcholinesterase
Joint Authors
Chautard-Freire-Maia, Eleidi A.
Mira, Marcelo Távora
Prevedello, Flávia Costa
Gomes, Henrique J. P.
Souza, Ricardo L. R.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Leprosy is a chronic disease caused by Mycobacterium leprae and affects the skin and the peripheral nervous system.
Butyrylcholinesterase is coded by the BCHE gene, and the atypical allele (70G; rs1799807) has been investigated as a leprosy risk factor, with conflicting results.
The present study estimated the frequencies of variants of rs1799807 and of five additional SNPs at the BCHE gene or near it: rs1126680, rs1803274, rs2863381, rs4440084, and rs4387996.
A total of 167 patients and 150 healthy controls were genotyped by TaqMan PCR.
Significantly higher allelic (70G) and genotypic (70DG) frequencies in rs1799807 were found in the patient group, with odds ratio (OR) of 6.33 (1.40 to 28.53) for the heterozygote.
This finding was replicated in a comparison of the cases against a control group of 361 blood donors.
The present data suggest that the atypical BChE variant may predispose to leprosy per se.
American Psychological Association (APA)
Gomes, Henrique J. P.& Souza, Ricardo L. R.& Prevedello, Flávia Costa& Mira, Marcelo Távora& Chautard-Freire-Maia, Eleidi A.. 2012. Investigation of Association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of Butyrylcholinesterase. Journal of Tropical Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-452719
Modern Language Association (MLA)
Gomes, Henrique J. P.…[et al.]. Investigation of Association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of Butyrylcholinesterase. Journal of Tropical Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-452719
American Medical Association (AMA)
Gomes, Henrique J. P.& Souza, Ricardo L. R.& Prevedello, Flávia Costa& Mira, Marcelo Távora& Chautard-Freire-Maia, Eleidi A.. Investigation of Association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of Butyrylcholinesterase. Journal of Tropical Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-452719
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452719