A Low Protein Diet Alters Bone Material Level Properties and the Response to In Vitro Repeated Mechanical Loading
Joint Authors
Ammann, Patrick
Dubois-Ferrière, Victor
Rizzoli, René
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Low protein intake is associated with an alteration of bone microstructure and material level properties.
However, it remains unknown whether these alterations of bone tissue could influence the response to repeated mechanical loading.
The authors investigated the in vitro effect of repeated loading on bone strength in humeri collected from 20 6-month-old female rats pair-fed with a control (15% casein) or an isocaloric low protein (2.5% casein) diet for 10 weeks.
Bone specimens were cyclically loaded in three-point bending under load control for 2000 cycles.
Humeri were then monotonically loaded to failure.
The load-displacement curve of the in vitro cyclically loaded humerus was compared to the contralateral noncyclically loaded humerus and the influence of both protein diets.
Material level properties were also evaluated through a nanoindentation test.
Cyclic loading decreased postyield load and plastic deflection in rats fed a low protein diet, but not in those on a regular diet.
Bone material level properties were altered in rats fed a low protein diet.
This suggests that bone biomechanical alterations consequent to cyclic loading are more likely to occur in rats fed a low protein diet than in control animals subjected to the same in vitro cyclic loading regimen.
American Psychological Association (APA)
Dubois-Ferrière, Victor& Rizzoli, René& Ammann, Patrick. 2014. A Low Protein Diet Alters Bone Material Level Properties and the Response to In Vitro Repeated Mechanical Loading. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-452741
Modern Language Association (MLA)
Dubois-Ferrière, Victor…[et al.]. A Low Protein Diet Alters Bone Material Level Properties and the Response to In Vitro Repeated Mechanical Loading. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-452741
American Medical Association (AMA)
Dubois-Ferrière, Victor& Rizzoli, René& Ammann, Patrick. A Low Protein Diet Alters Bone Material Level Properties and the Response to In Vitro Repeated Mechanical Loading. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-452741
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452741