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Patient-Specific Method of Generating Parametric Maps of Patlak Ki without Blood Sampling or Metabolite Correction : A Feasibility Study
Joint Authors
Seo, Youngho
Sayre, George A.
Franc, Benjamin L.
Source
International Journal of Molecular Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Currently, kinetic analyses using dynamic positron emission tomography (PET) experience very limited use despite their potential for improving quantitative accuracy in several clinical and research applications.
For targeted volume applications, such as radiation treatment planning, treatment monitoring, and cerebral metabolic studies, the key to implementation of these methods is the determination of an arterial input function, which can include time-consuming analysis of blood samples for metabolite correction.
Targeted kinetic applications would become practical for the clinic if blood sampling and metabolite correction could be avoided.
To this end, we developed a novel method (Patlak-P) of generating parametric maps that is identical to Patlak Ki (within a global scalar multiple) but does not require the determination of the arterial input function or metabolite correction.
In this initial study, we show that Patlak-P (a) mimics Patlak Ki images in terms of visual assessment and target-to-background (TB) ratios of regions of elevated uptake, (b) has higher visual contrast and (generally) better image quality than SUV, and (c) may have an important role in improving radiotherapy planning, therapy monitoring, and neurometabolism studies.
American Psychological Association (APA)
Sayre, George A.& Franc, Benjamin L.& Seo, Youngho. 2011. Patient-Specific Method of Generating Parametric Maps of Patlak Ki without Blood Sampling or Metabolite Correction : A Feasibility Study. International Journal of Molecular Imaging،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-452742
Modern Language Association (MLA)
Sayre, George A.…[et al.]. Patient-Specific Method of Generating Parametric Maps of Patlak Ki without Blood Sampling or Metabolite Correction : A Feasibility Study. International Journal of Molecular Imaging No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-452742
American Medical Association (AMA)
Sayre, George A.& Franc, Benjamin L.& Seo, Youngho. Patient-Specific Method of Generating Parametric Maps of Patlak Ki without Blood Sampling or Metabolite Correction : A Feasibility Study. International Journal of Molecular Imaging. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-452742
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452742